Chronic Kidney Disease – A plant-based diet prevents and treats CKD

Printable version: Chronic Kidney Disease – full article

Abstract

Interest in the dietary treatment of chronic kidney disease has been growing as its incidence has been increasing. Chronic Kidney Disease (CKD) is now the 8th leading cause of death in the United States and its treatment consumes substantial amounts of medical resources and money.

Several lines of epidemiological research have shown a lower risk of chronic kidney disease among vegetarians. It also shows a substantially increased risk among omnivores, especially those who eat red and processed meats.

Although the practice started long ago, research on the use of a low-protein plant-based diet to treat chronic kidney disease diet has intensified in recent years. This research has shown that a low-protein vegetarian diet is safe and efficacious at both treating and slowing the progression of chronic kidney disease.

Treatment with a low-protein vegetarian diet, often supplemented with keto analogues, has been shown to reduce acidosis, phosphotemia, uremia, proteinuria and to slow progression. Research shows that this treatment does not result in malnutrition. Research has also shown that larger amounts of plant protein than animal protein can be consumed, without deleterious effects.

Treatment with a low protein vegetarian diet also has the advantage of preventing and treating common comorbidities such as type 2 diabetes and coronary artery disease.

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Ensuring adequate vitamin B12 status for patients on a plant-based diet

Vitamin B12 is a water-soluble vitamin that is naturally present in animal-derived foods. It is added to others and is available as a dietary supplement and a prescription medication. Vitamin B12 exists in several forms and contains the mineral cobalt, (1, 2, 3, 4) so compounds with vitamin B12 activity are collectively called “cobalamins”. Methylcobalamin and 5-deoxyadenosylcobalamin are the forms of vitamin B12 that are active in human metabolism. (5) Continue reading

The Prevention and Treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet – published

We are delighted to announce that our comprehensive review article on the prevention and treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet was recently published in the peer-reviewed Endocrinology and Metabolism International Journal.

Here’s the published article as a pdf.

Review Article

The Prevention and Treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet

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Open Letter to Editor, JACC

Open Letter To the Editor-in-Chief, Journal of the American College of Cardiology

October 27, 2017

 

Dear Dr. Fuster,

In your recent update to the Expert Consensus Decision Pathway, (1) no specific mention was made of a safe and efficacious non-statin therapy, the plant-based diet.

Vegetarian and vegan diets can be very efficacious in reducing serum cholesterol and, importantly, LDL. Studies have shown that those following a plant-based diet have significantly lower total cholesterol and LDL levels. (2)
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Colon Cancer Prevention with a Plant-Based Diet

This article is also available in printable pdf form: Colon Cancer Prevention with a Plant-Based Diet

I. Executive Summary

It has long been known that vegetarians have a substantially reduced risk of colon cancer. Several studies have shown that vegetarians have a reduced risk of colon cancer of 46%-88%, and, as might be expected, a 54% reduced risk of colon adenoma, plus a 200% reduced risk of advanced adenoma. Vegetarians also have a lower prevalence of risk factors for colon cancer. These include a much lower risk of hyperinsulinemia secondary to metabolic syndrome, lower risk of obesity, and a much lower risk of Crohn’s disease. Vegetarians also have lower levels of CRP (cardio reactive protein) indicating a lower inflammatory status. This has also been correlated with a better prognosis for colon cancer.

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Rheumatoid Arthritis: Prevention and Treatment with a Plant-Based Diet

This article was published on Oct 5, 2018, in the peer-reviewed Orthopedics and Rheumatology Open Access Journal.

Abstract

Rheumatoid arthritis has no cure, so long term treatment is indicated. An individual’s dietary choices greatly influence the progression of chronic autoimmune rheumatic diseases. This review shows that the plant-based diet has good scientific evidence of safety and efficacy for both prevention and treatment of rheumatoid arthritis. Studies have shown significant improvements in specific symptoms, such as number of tender joints, Ritchie’s articular index, number of swollen joints, pain score, duration of morning stiffness, grip strength, and improved laboratory values such as sed rate (ESR), C-reactive protein, and rheumatic factor. Patients placed on a plant-based diet also have a beneficial shift in intestinal microbiota, which correlates with clinical improvement. With respect to prevention, those following a plant-based diet experience a reduction in risk of rheumatoid arthritis by about 50%.

RA patients should be advised that a plant-based diet that includes appropriate amounts of carbohydrate, especially dietary fiber, is important for maintaining the symbiosis of intestinal flora, which could be beneficial for preventing autoimmunity. As disease severity worsens, individuals with RA may experience functional decline that can impact dietary intake. New healthy plant-based convenience foods are a good choice for such patients.

 Treatment with a plant-based diet is affordable for the patient, has no adverse reactions and no contraindications, and it can be combined with any of the standard treatments. For mild cases it may suffice as a monotherapy. For moderate and severe cases, it may serve as an adjunct, allowing dosage reductions thus lessening the costs and side effects.

See Dr Chan Hwang, Physical Medicine and Rehab, talk about the treatment of Crohn’s Disease and Rheumatoid Arthritis with a plant-based diet:

 

Introduction

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown etiology. There is no cure, so long term treatment is indicated. Medication-based therapies comprise several classes of agents, including nonsteroidal anti-inflammatory drugs (NSAIDs), non-biologic and biologic disease modifying anti-rheumatic drugs (DMARDs), immunosuppressants, and corticosteroids. Other standard treatments include physical therapy and surgery.

Surveys have shown that a substantial proportion of people with RA will try complementary and alternative interventions, perhaps reflecting the lack of complete satisfaction with conventional approaches, and also a desire to help themselves. (1)  In 1989, Arthritis Care noted that more than 50% of the Arthritis Care members who were surveyed, had invested in “unorthodox medicines, substances, or treatments (including diets), during the prior six months”. (2)

Today, with increased access to health care information has come a growing demand for safe, cost-effective and easy to administer therapies. While a number of purported treatments have questionable or no research behind them, one of these so-called “unorthodox treatments” does.  An individual’s dietary choices can greatly influence the progression and manifestation of chronic autoimmune rheumatic diseases. In light of these effects, it makes sense that the search for additional therapies to attenuate such diseases would include investigations into dietary modifications. (3)

Dietary interventions have a widespread appeal for both patients as well as clinicians due to factors including affordability, accessibility, and presence of scientific evidences that demonstrate substantial benefits in reducing disease symptoms such as pain, joint stiffness, swelling, tenderness and associated disability with disease progression. (4)

Epidemiology

There have been few studies on the risk of RA in relation to vegetarian status.  However, one good-sized study showed that non-vegetarian women had a 57% increased risk of RA, and semi-vegetarians an increased risk of 16%, when compared with vegetarian women. Non-vegetarian men showed an increased risk of 50% and semi-vegetarian men an increased risk of 14%. (5) These results are especially notable considering that the non-vegetarians in this study already had a relatively low consumption of meat.

Interventional studies

Many doctors have anecdotally noted an association between the consumption of animal-derived foods, especially meat, and Rheumatoid Arthritis. (6)

A meta-study on RA looked at studies on the effects of short-term modified fasting followed subsequently with plant-based diets lasting at least three months. The pooling of these studies showed a statistically and clinically significant beneficial long-term effect. Thus available evidence suggests that fasting followed by vegetarian diets might be useful in the treatment of RA. (7)

The effect of a one-year study on RA patients of brief (7-10 day) modified fasting, followed first by a vegan diet and then by a vegetarian diet was assessed in a randomized, single blind controlled trial. After four weeks, the diet group showed a significant improvement in the number of tender joints, Ritchie’s articular index, number of swollen joints, pain score, duration of morning stiffness, grip strength, erythrocyte sedimentation rate, C reactive protein, white blood cell count, and a health assessment questionnaire score. The improvements were still present at the end of one year. A significant drop in the levels of intestinal Proteus Mirabilis was observed. (8)

In a follow-up study of the same patients two years later, pain score, duration of morning stiffness, Stanford Health Assessment Questionnaire index, number of tender joints, Ritchie’s articular index, number of swollen joints, ESR and platelet count all maintained their improvement in patients who were responders. Interestingly, most patients who were originally in the vegetarian group, but switched back to their usual diet, reported an increase in disease symptoms after intake of meat. (9)

A separate one-year study of RA patients placed on a vegetarian diet, and focusing on clinical laboratory values, showed significant improvements in leukocyte count, IgM, RF (Rheumatic Factor), and the complement components C3 and C4, along with patient symptoms. (10)

It usually takes several months for a plant-based diet to reach full effect in RA. However, one study showed improvements in pain, joint swelling, severity in morning stiffness and limitation in function in only 4 weeks. There were also non-significant trends in the reduction of C-reactive protein and Rheumatic factor. Based on the results of other studies, these might have become significant with further time. (11)

Studies have noted a link between vegan diets and protection against other autoimmune diseases. For example, an analysis of an Adventist cohort found that a vegan diet, but not a vegetarian diet, was associated with a lower risk of hypothyroid disease. (12)

Several researchers have examined the role of gut bacteria in RA disease activity. (13, 14, 15, 16, 17)  Researchers Ling and Hänninen tested subjects on both a conventional Western diet and a vegan diet for one month, in order to determine the shift in intestinal flora. They found that four fecal hydrolytic enzymes, associated with toxic and inflammatory products, diminished during consumption of the vegan diet. However, these changes in fecal urease, choloylglycine hydrolase, β-glucuronidase and β-glucosidase, disappeared within two weeks of resuming a conventional diet. The authors attribute these reductions in fecal enzymes not only to the activity of bacteria during the dietary shift, but also to the high fiber content of the vegan diet which can affect fecal weight, transit time and bacterial metabolism. (18)

RA patients have been found to have higher levels of Proteus mirabilis antibodies, when compared with healthy controls or subjects with other diseases. The subjects from the vegetarian diet study had a significantly lower mean antibody level against Proteus mirabilis, which was correlated significantly with the measured decrease in disease activity. (19) This suggests that the improvement in RA disease activity may be related to the effects of the vegan diet on the presence of gut bacteria, such as Proteus mirabilis, and the body’s response to such bacteria.

The possibility that a vegan diet can induce a rapid change in gut profile was supported by studies of rheumatoid arthritis patients, in which a one-month switch to a vegan diet was sufficient to significantly alter the fecal microflora, as determined by stool sample gas-liquid chromatography profiles of bacterial cellular fatty acids. (20, 21)

Peltonen et al. conducted a study of RA patients and found a significant change in intestinal flora after a one-year shift from a conventional diet to a vegan and then a lactovegetarian diet. They also noted a significant difference between the fecal flora of test subjects in the high improvement group and the low improvement group, suggesting a direct connection between gut profiles and levels of disease activity. (22)

To further test the role of diet-induced changes in levels of various intestinal flora on rheumatoid arthritis activity, 43 RA patients were randomly assigned to either a raw vegan diet rich in lactobacilli, or an omnivorous diet. After one month, there was a significant change in the fecal flora of the 18 subjects in the vegan diet group who completed the study; no such change was found in the omnivore control group. Importantly, the vegan diet also induced a decrease in disease activity in some of the RA patients, leading the authors to conclude that changes in the intestinal flora are associated with diet-induced changes in disease activity. (20)

Kjeldsen-Kragh et al. followed upon their work by putting rheumatoid arthritis patients on a fast followed by 3.5 months of a vegan diet, followed by a 9-month lactovegetarian diet. (23) Subjects in the vegan then vegetarian diet group improved significantly over those maintained on an omnivorous diet. Similar to other studies, the authors found that subjects’ fecal flora during times of clinical improvement differed significantly from times of no or minor improvements. Others have found that a raw vegan diet rich in lactobacilli and fiber decreased symptoms of rheumatoid arthritis, suggesting that the probiotic lactobacilli, among other components of a raw vegan diet, may be helpful to RA patients. (24, 25, 26) One way that these bacteria are helpful is that they regulate the T cell phenotype and T cell mediated immunity. (27)

Caution is warranted in interpreting bacteriologic studies on vegan diets and RA. Although diet-induced modification in intestinal flora, and an associated reduction in inflammation severity, may be a contributing factor to the improvements seen in RA patients, it is important to note that other features of a vegan diet have been credited with alleviating RA symptoms among vegan diet adherents. These include an increase in fruit, vegetable and fiber intake, a reduction in saturated fat and caloric intake, improved antioxidant levels, weight loss, and a reduction in food allergies and intolerances. (28, 29, 17)

It has been observed that vegetarians consume enough foods naturally containing salicylates to have an anti-inflammatory effect. The presence of salicylate in the blood of patients placed on a vegetarian diet was found at concentrations that are known to inhibit the transcription of COX 2, a key inflammatory enzyme in various pathologies. An emphasis on those foods highest in salicylate might enhance the therapeutic effect of a plant-based diet and warrants further investigation. (30)

The low-fat vegan diet and diets rich in unsaturated fat (such as plant-based oils) or probiotics have positive effects at alleviating pain and on inflammation markers. (31) There was much hope for the role for Omega 3 fatty acids from fish oil. However, clinical studies on supplementation of ω-3 fatty acids have not supported the expectations. (32, 33, 34, 35, 36, 37)

Reduction of risk of Coronary Artery Disease (CAD)

Patients with rheumatoid arthritis (RA) have increased cardiovascular disease and mortality. (38, 39, 40) Several recent studies indicate an increased prevalence not only of cardiovascular disease (CVD) but also of atherosclerosis as determined by ultrasound tomography of carotid arteries. (38, 41, 42) The underlying mechanisms causing this increased risk are not wholly clarified but inflammation and disease duration are suggested to be of importance. (43, 44, 45, 46)

One study investigated the effects of a vegan diet, in patients with rheumatoid arthritis (RA), on the blood lipids: oxidized low-density lipoprotein (oxLDL) and on natural atheroprotective antibodies against phosphorylcholine (anti-PCs). The study examined the effects of intervention using a gluten-free vegan diet on patients with active RA. They were randomly assigned to either a vegan diet or a well-balanced non-vegan diet for one year. The gluten-free vegan diet induced significantly lower body mass index (BMI), low density lipoprotein (LDL), ox LDL, total cholesterol, and higher anti-PC IgM than control diet. Triglycerides and high-density lipoprotein did not change, since this was not a low fat vegan diet. Therefore a vegan diet in patients with RA induces changes that are potentially atheroprotective and anti-inflammatory, including decreased LDL and oxLDL levels, and raised anti-PC IgM and IgA levels. (47)

Clinical Considerations

Rheumatoid arthritis (RA) afflicts approximately 1.5 million American adults and is a major cause of disability. As disease severity worsens, individuals with RA may experience functional decline that can impact dietary intake. The diet quality of many individuals with RA needs improvement and may be related to functional disability associated with RA. Healthcare providers should encourage individuals with RA to meet dietary guidelines and maintain a healthy diet. Moreover, healthcare providers should be aware of the potential impacts of functional disability on diet quality in individuals with RA. (48)

Patients with rheumatoid arthritis often have trouble preparing foods that require manual dexterity and strength. These patients should be counseled to purchase the new healthy plant-based convenience foods that are now widely available. These foods are usually higher in fiber and lower in sugar, fat, sodium and calories than ordinary convenience foods. (49)

RA patients should be advised that a plant-based diet that includes appropriate amounts of carbohydrate, especially dietary fiber, is important for maintaining the symbiosis of intestinal flora, which could be beneficial for preventing autoimmunity. (27)

Active participation of the patient and family in the design and implementation of the therapeutic program helps ensure compliance, as does explaining the rationale for dietary treatment.

 This treatment may be sufficient as a monotherapy in mild cases, or can be used as an adjunct to standard treatments in moderate and severe cases. Dosages may be able to be titrated down as the clinical effects of the diet manifest themselves.

 

Discussion

Optimal care of patients with rheumatoid arthritis consists of an integrated approach that includes both pharmacologic and non-pharmacologic therapies. Medications have side effects which must be managed and are costly to the patient. Some of the non-pharmacologic treatments are available for this disease include physical therapy and surgery. (50) A plant-based diet should be added to this list.

Studies show that not only is a plant-based diet safe and efficacious for the prevention and treatment of Rheumatoid Arthritis, it has several advantages in its favor. It has no adverse effects, no contraindications, and it’s very affordable for the patient.  It can be combined with any standard treatment, and is likely to synergize treatments effects with them. It is safe in the long term, and has been shown to reduce the risk of comorbidities, such as coronary artery disease, in rheumatoid arthritis patients.

Further research should focus on the most effective dietary elements within plant-based diets.

Conflict of Interest

The authors state no conflicts of interest or funding sources.

References

 

1.

Ernst E. (2004) Musculoskeletal conditions and complementary/alternative medicine. Best Practice & Research Clinical Rheumatology 18(4):539–556.

2.

Darlington L. (1991) Dietary therapy for arthritis. Rheumatic Disease Clinics Of North America 17(2):273-286.

3.

Dahan S, Segal Y, Shoenfeld Y. (2017) Dietary factors in rheumatic autoimmune diseases: a recipe for therapy? Nat Rev Rheumatol J13(6):348-358.

4.

Khanna S, Jaiswal K, Gupta B. (2017) Managing Rheumatoid Arthritis with Dietary Interventions. Front Nutr 4:52.

5.

Fraser G. (1999) Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. American Journal of Clinical Nutrition 70(3):532s-538s.

6.

Kutlu A, Oztürk S, Taşkapan O, Onem Y, Kiralp MZ, et.al. (2010) Meat-induced joint attacks, or meat attacks the joint: rheumatism versus allergy. Nutrition in Clinical Practice 25(1):90-91.

7.

Müller H, de Toledo F, Resch K. (2001) Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review. Scandinavian Journal of Rheumatology 30(1):1-10.

8.

Kjeldsen-Kragh J, Haugen M, Borchgrevink C, et.al. (1991) Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. The Lancet.338(8772):899-902.

9.

Kjeldsen-Kragh J, Haugen M, Borchgrevink C, Førre O. (1994) Vegetarian diet for patients with rheumatoid arthritis–status: two years after introduction of the diet. Clinical Rheumatology 13(3):475-482.

10.

Kjeldsen-Kragh J, Mellbye O, Haugen M, Mollnes TE, Hammer HB, et.al. (1995) Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet. Scandinavian Journal of Rheumatology 24(2):85-93.

11.

McDougall J, Bruce B, Spiller G, Westerdahl J, McDougall, M. (2002) Effects of a very low-fat, vegan diet in subjects with rheumatoid arthritis. Journal of Alternative and Complementary Medicine. 8(1):71-75.

12.

Tonstad S, Nathan E, Oda K, Fraser G. (2013) Vegan Diets and Hypothyroidism. Nutrients. 5(11):4642-4652.

13.

Hazenberg M, Klasen I, Kool J, Ruseler-van Embden JG, Severijnen AJ. (1992) Are intestinal bacteria involved in the etiology of rheumatoid arthritis? Review article. APMIS. 100(1):1-9.

14.

Deighton C, Gray J, Bint A, Walker DJ. (1992) Anti-Proteus antibodies in rheumatoid arthritis same-sexed sibships. British Journal of Rheumatology. 31(4):241-245.

15.

Ebringer A, Ptaszynska T, Corbett M, Wilson C, Macafee Y et al. (1985) Antibodies to Proteus in Rheumatoid Arthritis. The Lancet. 326(8450):305–307.

16.

Rogers P, Hassan J, Bresnihan B, Feighery C, Whelan A. (1988) Antibodies to Proteus in rheumatoid arthritis. British Journal of Rheumatology. 27 Suppl 2:90-94.

17.

Glick-Bauer M, Yeh MC. (2014) The Health Advantage of a Vegan Diet: Exploring the Gut Microbiota Connection. Nutrients. 6(11):4822-4838.

18.

Ling W, Hänninen O. (1992) Shifting from a conventional diet to an uncooked vegan diet reversibly alters fecal hydrolytic activities in humans. Journal of Nutrition. 122(4):924-930.

19.

Kjeldsen-Kragh J, Rashid T, Dybwad A, Ebringer A. (1995) Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet. Annals of the Rheumatic Diseases. 54(3):221-224.

20.

Peltonen R, Nenonen M, Helve T, Hänninen O, Toivanen P, et al. (1997) Faecal microbial flora and disease activity in rheumatoid arthritis during a vegan diet.. British Journal of Rheumatology. 36(1):64-68.

21.

Peltonen R, Ling W, Hänninen O, Eerola E. (1992) An uncooked vegan diet shifts the profile of human fecal microflora: Computerized analysis of direct stool sample gas-liquid chromatography profiles of bacterial cellular fatty acids. Applied and Environmental Microbiology. 58(11):3660-3666.

22.

Peltonen R, Kjeldsen-Kragh J, Haugen M, Eerola E. (1994) Changes of faecal flora in rheumatoid arthritis during fasting and one-year vegetarian diet. British Journal of Rheumatology. 33(7):638-643.

23.

Kjeldsen-Kragh J. (1999) Rheumatoid arthritis treated with vegetarian diets. American Journal of Clinical Nutrition. 70(3 Suppl):594s-600s.

24.

Nenonen M, Helve T, Rauma A, Hänninen OO. (1998) Uncooked, lactobacilli-rich, vegan food and rheumatoid arthritis. British Journal of Rheumatology. 37(3):274-281.

25.

Hänninen O, Rauma A, Kaartinen K, Nenonen M. (1999) Vegan diet in physiological health promotion.. Acta Physiologica Hungarica. 86(3-4):171-180.

26.

Hänninen O, Kaartinen K, Rauma A, Nenonen M, Törrönen R, et.al. (2000) Antioxidants in vegan diet and rheumatic disorders. Toxicology. 155(1-3):45-53.

27.

Masuko K. (2018) A Potential Benefit of “Balanced Diet” for Rheumatoid Arthritis. Front Med (Lausanne). 5:141.

28.

Smedslund G, Byfuglien M, Olsen S, Hagen K. (2010) Effectiveness and safety of dietary interventions for rheumatoid arthritis: A systematic review of randomized controlled trials.. Journal of the American Dietetic Assoc..110(5):727-35.

29.

Hafström I, Ringertz B, Spångberg A, von Zweigbergk L, Brannemark S, et.al. (2001) A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: The effects on arthritis correlate with a reduction in antibodies to food antigens. Rheumatology (Oxford). 40(10):1175-1179.

30.

Blacklock C, Lawrence J, Wiles D, Malcolm EA, Gibson IH, et.al. (2001) Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin. Journal of Clinical Pathology. 54(7):553-555.

31.

Badsha H. (2018) Role of Diet in Influencing Rheumatoid Arthritis Disease Activity. Open Rheumatol J. 12:19-28.

32.

Haugen M, Fraser D, Forre O. (1999) Diet therapy for the patient with rheumatoid arthritis? Rheumatology (Oxford). 38(11):1039-1044.

33.

Pullman-Mooar S, Laposata M, Lem D, Holman RT, Leventhal LJ, et.al. (1990) Alteration of cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid. Arthritis and Rheumatism. 33(10):1526-1533.

34.

Kremer J, Jubiz W, Michalek A, Rynes RI, Bartholomew LE, et.al. (1987) Fish-Oil Fatty Acid Supplementation in Active Rheumatoid Arthritis: A Double-Blinded, Controlled, Crossover Study. Annals of Internal Medicine. 106(4):497-503.

35.

Tate G, Mandell B, Laposata M, Ohliger D, Baker DG, et.al. (1989) Suppression of acute and chronic inflammation by dietary gamma linolenic acid.. Journal of Rheumatology. 16(6):729-734.

36.

Endres S, Ghorbani R, Kelley V, Georgilis K, Lonnemann G, et.al. (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine. 320(5):265-271.

37.

Kjeldsen-Kragh J, Lund J, Riise T, Finnanger B, Haaland K, et.al. (1992) Dietary omega-3 fatty acid supplementation and Naproxen treatment in patients with rheumatoid arthritis. Journal of Rheumatology. 19(10):1531-1536.

38.

Frostegård J. (2005) Atherosclerosis in patients with autoimmune disorders. Arteriosclerosis, Thrombosis and Vascular Biology. 25(9):1776-85.

39.

Solomon D, Karlson E, Rimm E, Cannuscio CC, Mandi LA, et.al. (2003) Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis.. Circulation. 107(9):1303-1307.

40.

Wolfe F, Freundlich B, Straus W. (2003) Increase in cardiovascular and cerebrovascular disease prevalence in rheumatoid arthritis.. Journal of Rheumatology. 30(1):36-40.

41.

Park Y, Ahn C, Choi H, Lee SH, In BH, et.al. (2002) Atherosclerosis in rheumatoid arthritis: morphologic evidence obtained by carotid ultrasound.. Arthritis and Rheumatism. 46(7):1714-9.

42.

Jonsson S, Backman C, Johnson O, Karp K, Lundström E, et.al. (2001) Increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis. Journal of Rheumatology. 28(12):2597-2602.

43.

Del Rincón I, Williams K, Stern M, Freeman GL, O’Leary DH, et.al. (2003) Association between carotid atherosclerosis and markers of inflammation in rheumatoid arthritis patients and healthy subjects. Arthritis and Rheumatism. 48(7):1833-1840.

44.

Nagata-Sakurai M, Inaba M, Goto H, Kumeda Y, Furumitsu Y, et.al. (2003) Inflammation and bone resorption as independent factors of accelerated arterial wall thickening in patients with rheumatoid arthritis. Arthritis and Rheumatism. 48(11):3061-3067.

45.

Wållberg-Jonsson S, Cvetkovic J, Sundqvist K, Lefvert AK, Rantapää-Dahlqvist S. (2002) Activation of the immune system and inflammatory activity in relation to markers of atherothrombotic disease and atherosclerosis in rheumatoid arthritis.. Journal of Rheumatology. 29(5):875-882.

46.

Del Rincón I, O’Leary D, Freeman G, Escalante A. (2007) Acceleration of atherosclerosis during the course of rheumatoid arthritis.. Atherosclerosis. 195(2):354-360.

47.

Elkan A, Sjöberg B, Kolsrud B, Ringertz B, Hafström I, Frostegård J, et.al. (2008) Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study. Arthritis Research & Therapy. 10(2):R34.

48.

Berube L, Kiely M, Yazici Y, Woolf K. (2017) Diet quality of individuals with rheumatoid arthritis using the Healthy Eating Index (HEI)-2010. Nutr Health. 23(1):17-24.

49.

Mizukami Y, Matsui T, Tohma S, Masuko K. (2017) Distinct patterns of dietary intake in different functional classes of patients with rheumatoid arthritis. Top Clin Nutr. 32(2):141-151.

50.

National Collaborating Centre for Chronic Conditions (UK). (2009) Rheumatoid Arthritis: National Clinical Guideline for Management and Treatment in Adults. London: Royal College of Physicians (UK).

Type 2 Diabetes: Prevention & Treatment with a Plant-Based Diet

The Prevention and Treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet 

Printable pdf version (25 pages) : Type 2 Diabetes article

  1. Introduction

Today’s physicians are only too aware of the prevalence of Type 2 Diabetes Mellitus (T2DM) currently in America, and of its complications such as diabetic peripheral neuropathy and diabetic nephropathy. The increased risk of coronary artery disease that type 2 diabetics face is on every physician’s mind. Administrators and policy makers grapple with the dollar cost to the health care system from type 2 diabetes, and perhaps most worrisome of all, the rise in obesity and metabolic syndrome tells public health officials that the problem will likely get worse if nothing changes.

This article presents evidence of the safety and efficacy of plant-based diets for prophylaxis and treatment of type 2 diabetes mellitus.

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